In collaboration with Brigham and Women’s Hospital, the major goals for this project are: Aggregation of Extant CHR-related Data Sets; Management, Direction, Data Processing and Coordination of U01 Multisite Network; and to Develop and Apply CHR Stratification Tools to Identify and Validate Biomarkers to Predict Individual Outcome Trajectories.
In collaboration with Milissa Kaufman, the goals of this study will be 1) to understand the differential biomarkers that map onto dissociative symptoms, and 2) to understand how these biomarkers may best predict trajectory of response to empirically based standard-of-care treatments. This naturalistic study will allow us to map the biology of dissociation, and importantly, […]
Inpatient psychiatric treatment settings provide care for individuals with a range of behavioral disturbances and psychopathology, which often manifests as profound alterations in the amount and nature of physical behavior. We aim to establish an efficient and consistent process to identify clinically significant levels of physical activity (e.g., sleep, restlessness, agitation) that could both prove […]
This is a neuroimaging study conducted in collaboration with Avram Holmes’ lab at Yale University focusing on neurogenetic factors related to unipolar and bipolar depression. The goal of this project is to identify genetic contributors to the functioning of large-scale brain networks and characterize their relationship to dimensional symptom profiles in patients with affective and […]
Deep phenotyping dashboard: DPdash is a Deep/Digital Phenotyping Dashboard designed to manage and visualize multiple data streams coming in continuously over extended periods of time in individuals. At its core, DPdash is a web-viewable dashboard that allows users to visualize continuously acquired dynamic data coming in from multiple data streams that can include smartphone-based passive […]
The major goal of this supplemental project was to explore the ethical, legal, and social implications of the intensive computational phenotyping work accomplished in the parent project and related projects.