Naturalistic paradigms hold enormous potential for studying abnormal brain function. However, the development of clinical applications based on naturalistic approaches is still in its infancy. Our symposium at OHBM 2023 presented the challenges and recent advances in research directed at clinical translation of naturalistic paradigms for brain mapping.More
This is a neuroimaging study conducted at McLean Hospital which is focused on studying changes in functional brain network architecture in patients with OCD over the course of intensive, residential treatment.More
Research on affective disorders, such as bipolar disorder, and on psychotic disorders is hampered by a lack of basic understanding of the course of dynamic circuit properties that might underlie fluctuations in mood and cognition.Bipolar and psychotic disorders at its core are unstable clinical conditions: at its extremes, it can result in periods of profound changes in mood and cognition (i.e., mania, major depression, and psychosis). And yet, remarkably little has been done to understand the basic mechanisms underlying the fluctuating course common to these individuals. We hope to better understand and characterize the natural course of changes in mood and cognition and associated environmental variables in individuals with severe affective and psychotic disorders using mobile behavioral technology. We believe that this will further enable advances in our understanding of how these disorders develop, paving the way for the development and evaluation of new treatment strategies.