Circuit dynamics underlying longitudinal fluctuations in mood and cognition in bipolar patients

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Research on affective disorders, such as bipolar disorder, and on psychotic disorders is hampered by a lack of basic understanding of the course of dynamic circuit properties that might underlie fluctuations in mood and cognition.Bipolar and psychotic disorders at its core are unstable clinical conditions: at its extremes, it can result in periods of profound changes in mood and cognition (i.e., mania, major depression, and psychosis). And yet, remarkably little has been done to understand the basic mechanisms underlying the fluctuating course common to these individuals. We hope to better understand and characterize the natural course of changes in mood and cognition and associated environmental variables in individuals with severe affective and psychotic disorders using mobile behavioral technology. We believe that this will further enable advances in our understanding of how these disorders develop, paving the way for the development and evaluation of new treatment strategies.