Neuroimaging

Circuit dynamics underlying longitudinal fluctuations in mood and cognition in bipolar patients

FNIBI / Current Projects / A Year in the Life, Actigraphy, Arterial Spin Labeling, Audio Diary Recording, Bipolar Disorder, Completed Projects, Depression, Dyadic Recording, Ecological Momentary Assessment, Eye-tracking, Facial Recording, Functional MRI, Neurocognitive Tasks, Neuroimaging, Schizophrenia, Smartphone, Social Signal Processing Algorithms /

January 1, 2018

Research on affective disorders, such as bipolar disorder, and on psychotic disorders is hampered by a lack of basic understanding of the course of dynamic circuit properties that might underlie fluctuations in mood and cognition.Bipolar and psychotic disorders at its core are unstable clinical conditions: at its extremes, it can result in periods of profound changes in mood and cognition (i.e., mania, major depression, and psychosis). And yet, remarkably little has been done to understand the basic mechanisms underlying the fluctuating course common to these individuals. We hope to better understand and characterize the natural course of changes in mood and cognition and associated environmental variables in individuals with severe affective and psychotic disorders using mobile behavioral technology. We believe that this will further enable advances in our understanding of how these disorders develop, paving the way for the development and evaluation of new treatment strategies.

Frontoparietal Network Integrity and Risk for Psychosis

FNIBI / Past Projects / Functional MRI, Genetics, Neuroimaging, Psychosis /

April 1, 2014

The major goal of this study was to probe the biology of the frontoparietal control network, a key brain network engaged in higher cognition and disrupted in chronic in psychosis by linking genetics, neuroimaging and clinical variables in individuals at clinical and genetic high risk for psychosis.

Evaluating the Neurobiological Basis of Traumatic Dissociation in a Cross-Diagnostic Sample of Women with Histories of Childhood Abuse and Neglect

FNIBI / Past Projects / Dissociation, Dissociative Identity Disorder, Functional MRI, Neuroimaging, Posttraumatic Stress Disorder, Trauma /

April 1, 2014

In collaboration with Kerry Ressler and Milissa Kaufman, the major goals of this study were to characterize brain system abnormalities present in patients with dissociative symptoms and diagnoses of either post-traumatic stress disorder or dissociative identity disorder.

Functional Biomarkers of Psychotic State, Trait, and Compensation in Schizophrenia and Related Disorders Using Resting State Imaging

FNIBI / Past Projects / Bipolar Disorder, Functional MRI, Neuroimaging, Schizophrenia /

April 1, 2013

The major goals of this study were to characterize the state-dependent nature of brain abnormalities in individuals with schizophrenia and bipolar disorder using functional imaging, and to define biological biomarkers of clinical state, trait, and compensation.

Neural Basis for Psychomotor Variation in Schizophrenia

FNIBI / Past Projects / Eye-tracking, Functional MRI, Genetics, Neuroimaging, Schizophrenia /

April 1, 2011

The major goals of this study were to use eye-tracking, genetics and functional MRI to study psychomotor symptoms in schizophrenia

Vincent Holstein, MD MSc

FNIBI / People / A Year in the Life, Inpatient Activity, Neuroimaging /

January 1, 2010

Dr. Holstein is a postdoc at the Neurogenomics and Translational Bioinformatics Laboratory (NG-TBL) at McLean Hospital since January 2023. He is interested in the extraction of features from actigraphy data and using psychometrics and biomarkers to predict treatment responses in diverse psychiatric populations.

Yoonho Chung, PhD

FNIBI / People / A Year in the Life, Digital phenotyping, Neuroimaging /

January 1, 2010

TBA

Josh Salvi, MD PhD

FNIBI / Alumni / Neuroimaging /

January 1, 2010

Josh is a resident in the Research Concentration Program as part of the MGH/McLean Adult Psychiatry Residency Program, arriving here after completing his tenure at the Weill Cornell / Rockefeller / Sloan-Kettering Tri-Institutional MD-PhD Program in New York City. His background is in neuroscience, biophysics, and dynamical systems. He employed a combination of micromechanical, electrophysiological, and computational techniques to find that sensory hair bundles are controlled not simply by their genetics, but by their mechanical microenvironment.

Poornima Kumar, PhD

FNIBI / Collaborators / Depression Imaging, Neuroimaging /

January 1, 2010

Poornima is an assistant professor of psychiatry at Harvard Medical School and an assistant neuroscientist at McLean Hospital. Her research interests focus on investigating the mechanisms through which humans learn and process reinforcements (both rewards and punishments) and how these processes might contribute to psychiatric disorders, particularly depression.

Neuroimaging Correlates of Genetic and Clinical Variables in Schizophrenia and Bipolar Disorder

FNIBI / Past Projects / Bipolar Disorder, Functional MRI, Genetics, Neuroimaging, Schizophrenia /

April 1, 2008

In collaboration with Dost Ongur, the major goals of this study were to characterize any brain system abnormalities present in patients who are experiencing psychotic or manic symptoms, and relate these patterns to specific genetic variables (e.g., single nucleotide polymorphisms) and clinical findings (e.g., presence or absence of hallucinations or delusions).